… the receptors of androgens, progesterone, estrogen, and thyroid hormones, as well as their
… as well as cause female biased sex ratio in amphibians. Simultaneously, the excess of T can …

… Spontaneous pregnancy loss (miscarriage, ie fetal death … oestrogen activity due to the
variations in ESR1 of the fetal … For instance, is there a critical hormonal imbalance to the fetal …

… in fetus, suggesting that enzyme is not related to male fetal … female mice with transgenic
disruption of 5α-reductase type 1 (… trends pointing toward an increased likelihood of affected 46,…

… a crucial role in embryonic development, cellular differentiation … of steroid hormones is
demonstrated by states of excess and … 5α-reductase (5αR) type 1 and 2 convert GCs and AGs to …

… during the fetal period and later during puberty. Its deficiency … were described, type 1 the
first cloned and type 2 the second … excessive bone maturation except in tall girls, in whom adult …

… Increased 5α-reductase or decreased 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1…
activity likely protects the fetus from exposure to the increased circulating androgen levels in …

… Human Hydroxysteroid (17beta) dehydrogenase 1 (HSD17B1) enzyme shows a high
capacity to produce the highly active estrogen, estradiol, from a precursor hormone, estrone. …

… of 5αR1 protein was increased in skeletal muscle of PCOS rats, and exercise … of 5alpha-reductase
inhibition with dutasteride and finasteride on semen parameters and serum hormones …

… Mice lacking Rxfp1 or Rln have parturition defects that in part … function and increased
responsiveness to estrogen. In … encoding 5alpha-reductase type 1 (5α-R1) are induced in …

… Moreover, aromatase (CYP19A1) mutations inhibiting the aromatase activity and the
conversion of androgens to estrogens, cause fetal and maternal androgen excess during …